Author:
Houreisen Skin Clinic, specializing in nasolabial fold and wrinkle treatment
Osaka Houreisen Cosmetic Dermatology /
Tokyo Houreisen Skin Clinic /
Nagoya Houreisen Skin Clinic
Shinya Sasagawa, Representative Director, Medical Corporation Shingetsukai
View Doctor Profile
Sunekos at a Glance
Sunekos is an injectable skin-quality treatment designed to improve fine lines, firmness, elasticity, hydration, and the overall condition of the skin.
It is particularly suitable for concerns such as:
- Fine lines around the eyes
- Fine wrinkles on the neck
- Under-eye dark circles related to thin or lax skin
- Loss of skin firmness and elasticity
- Enlarged pores
- Redness
- Dull or tired-looking skin
- Uneven skin texture
At our clinic, we have also observed improvement in facial redness in appropriately selected patients. Although Sunekos is not a treatment that directly removes dilated blood vessels, improving hydration, dermal condition, and overall skin quality may reduce the visible appearance of redness in some patients.
However, Sunekos is not a treatment that can correct every type of wrinkle or facial aging.
Sunekos alone is generally not sufficient when the main concern is:
- Deep nasolabial folds
- Pronounced marionette lines
- Significant facial skin laxity
- Depressions caused by bone structure
- Substantial facial volume loss
- Wrinkles caused primarily by strong muscle movement
In these cases, treatments such as Growth Factor Therapy, hyaluronic acid fillers, Botox®, thread lifts, HIFU, or radiofrequency treatments may be more appropriate, depending on the underlying cause.
The important question is not simply whether Sunekos works. The more important question is whether Sunekos matches the cause of your specific concern.
Could Sunekos Be Right for Your Skin Concerns?
- Fine lines around your eyes are becoming more noticeable.
- Your under-eye area makes you look tired.
- Your skin has become thinner, drier, or less firm.
- You are concerned about enlarged pores, redness, or dullness.
- Your skin no longer looks smooth even when you apply foundation.
- You want to improve skin quality without significantly changing your facial contours.
- You prefer gradual, natural-looking improvement rather than obvious volumization.
- You want to improve the overall health and appearance of your skin.
If any of these concerns sound familiar, Sunekos may be an appropriate treatment option.
However, fine lines and wrinkles do not all develop for the same reason. They may be caused by:
- Reduced skin hydration and elasticity
- Thinning or atrophy of the dermis
- Repeated facial muscle movement
- Loss or redistribution of facial fat
- Changes in facial bone structure
- Skin laxity
At Houreisen Skin Clinic, we do not select treatment based only on the visible wrinkle. We evaluate the underlying cause and recommend the treatment most likely to produce a balanced, natural-looking result.
目次
- Sunekos at a Glance
- Could Sunekos Be Right for Your Skin Concerns?
- What Is Sunekos?
- What Is Non-Crosslinked Hyaluronic Acid?
- The Six Amino Acids in Sunekos
- Sunekos Performa and Sunekos 1200
- What Can Sunekos Improve?
- Sunekos for Redness and Dullness
- Can Sunekos Improve Melasma?
- Sunekos for Fine Lines and Skin Laxity
- Sunekos for Under-Eye Dark Circles
- How Many Sunekos Treatments Are Recommended?
- How Long Do the Effects of Sunekos Last?
- Who May Benefit from Sunekos?
- When Sunekos Alone May Not Be Enough
- Our Approach to Sunekos Treatment
- Combining Sunekos with Botox®
- How Sunekos Compares with Other Injectable Treatments
- Sunekos vs. Profhilo®
- Sunekos or Profhilo® for the Under-Eye Area?
- Is Sunekos Effective for Nasolabial Folds?
- For Deeper Nasolabial Folds, Another Treatment May Be More Suitable
- Risks, Side Effects, and Limitations of Sunekos
- Frequently Asked Questions
- Sunekos Pricing at Our Clinic
- Is Sunekos Right for You?
What Is Sunekos?
Sunekos is an injectable product developed in Italy. It contains non-crosslinked hyaluronic acid combined with six amino acids in a patented formulation.
Sunekos is injected into areas affected by skin aging, such as the:
- Under-eye area
- Around the eyes
- Forehead
- Cheeks
- Around the mouth
- Neck
- Décolletage
- Back of the hands
The treatment is designed to support the production of collagen and elastin and improve the condition of the extracellular matrix, which is the structural environment surrounding the cells within the skin.
Unlike conventional dermal fillers, Sunekos is not primarily intended to add volume or reshape the face.
Instead, it is used to improve:
- Skin hydration
- Firmness and elasticity
- Fine lines
- Skin texture
- Pore appearance
- Redness and dullness in selected patients
- Overall skin quality
In daily practice, patients considering Sunekos often tell us:
- “I do not want to dramatically change my face, but I look tired.”
- “I am concerned about fine lines and dark circles around my eyes.”
- “My skin has lost its firmness and glow.”
- “My skin is becoming redder and more uneven.”
- “I want my skin to look healthier, not overtreated.”
For these concerns, improving the condition of the skin itself may be more appropriate than simply adding volume.
What Is Non-Crosslinked Hyaluronic Acid?
One of the defining features of Sunekos is that it contains non-crosslinked hyaluronic acid.
Hyaluronic acid is naturally present in the human body and plays an important role in maintaining skin hydration.
In conventional dermal fillers, hyaluronic acid molecules are chemically linked together through a process called crosslinking. Crosslinking makes the product more resistant to degradation and allows it to retain its shape and provide structural volume.
Sunekos is different.
Because the hyaluronic acid in Sunekos is not crosslinked, it is softer and more fluid than conventional volumizing fillers. It is intended to spread within the treated tissue and improve skin condition rather than create a clearly defined shape.
This characteristic makes Sunekos particularly useful for delicate areas such as the under-eye region, where excessive firmness or volume may create an unnatural appearance.
Sunekos does not improve fine lines by simply filling them with bulk. Instead, it supports hydration and the skin’s natural regenerative processes, gradually improving firmness, elasticity, and texture.
Does Non-Crosslinked Hyaluronic Acid Cause Vascular Occlusion?
Vascular occlusion is a rare but serious complication that may occur when an injectable product enters or compresses a blood vessel and reduces blood flow.
Sunekos is a low-viscosity, non-crosslinked hyaluronic acid product and is not used in the same way as a conventional structural dermal filler.
At Houreisen Skin Clinic, we have not experienced a case of vascular occlusion caused by Sunekos treatment.
This is an important part of our clinical experience. However, it would not be medically appropriate to state that vascular complications are absolutely impossible with any injectable procedure.
Safe treatment still requires:
- Accurate knowledge of facial anatomy
- Appropriate patient selection
- Careful control of injection depth and placement
- Recognition of unexpected pain, discoloration, or circulatory changes
- Prompt medical assessment if an abnormal reaction occurs
More common side effects include temporary swelling, redness, bruising, tenderness, and small bumps at the injection sites.
The Six Amino Acids in Sunekos
Sunekos combines non-crosslinked hyaluronic acid with the following six amino acids:
| Amino Acid | Role in the Formulation |
|---|---|
| Glycine | One of the amino acids involved in collagen and extracellular matrix protein synthesis. |
| L-Proline | Supports the synthesis and maintenance of structural proteins within the skin. |
| L-Lysine | Contributes to protein synthesis and the maintenance of connective tissue. |
| L-Alanine | Supports cellular metabolism and tissue maintenance. |
| L-Valine | One of the essential amino acids involved in protein synthesis and cellular repair. |
| L-Leucine | Supports protein synthesis and tissue repair processes. |
The value of Sunekos does not depend on one amino acid acting alone. The six amino acids are combined in a specific patented ratio with hyaluronic acid to support the skin’s extracellular matrix and regenerative environment.
The extracellular matrix is the structural network surrounding skin cells. It includes collagen, elastin, fibronectin, hyaluronic acid, and other components involved in maintaining skin strength, elasticity, and hydration.
Sunekos Performa and Sunekos 1200
Sunekos treatment includes different formulations designed for different degrees and patterns of skin aging.
Sunekos Performa
Sunekos Performa is the successor to the original Sunekos 200 and is the standard Sunekos product used at our clinic.
It is primarily used to improve:
- Fine lines
- Under-eye skin quality
- Skin hydration
- Firmness and elasticity
- Enlarged pores
- Redness
- Dullness
- Overall skin texture
Compared with the original Sunekos 200 formulation, Sunekos Performa contains a greater quantity of amino acids and a higher concentration of non-crosslinked hyaluronic acid.
At our clinic, we have used Sunekos Performa as our standard Sunekos treatment since April 2024.
Sunekos 1200
Sunekos 1200 contains hyaluronic acid with different molecular characteristics and has a higher viscosity than Sunekos Performa.
It may be considered when the patient has:
- More advanced skin aging
- Marked dermal atrophy
- Deeper wrinkles
- Reduced structural support within the skin
- Skin thinning associated with facial hollowing
Sunekos 1200 is not equivalent to a conventional volumizing dermal filler. It is generally used to provide additional dermal support and may be combined with Sunekos Performa when treating more advanced aging changes.
Comparison of Sunekos Performa and Sunekos 1200
| Sunekos Performa | Sunekos 1200 | |
|---|---|---|
| Primary Role | Improvement of overall skin quality, fine lines, hydration, firmness, and elasticity | Additional support for more advanced skin aging, deeper wrinkles, and marked dermal atrophy |
| Texture | Lower viscosity and suitable for detailed treatment of delicate areas | Higher viscosity and intended to provide greater dermal support |
| Common Treatment Areas | Face, around the eyes, under-eye area, neck, décolletage, and hands | Selected facial areas with more advanced skin aging or dermal atrophy |
| Use at Our Clinic | Standard formulation for most patients | Used selectively, often in combination with Sunekos Performa |
At Houreisen Skin Clinic, the formulation is selected according to the patient’s skin condition, degree of aging, treatment area, and desired outcome.
What Can Sunekos Improve?
Sunekos is primarily a skin-quality treatment. It is designed to improve the structure and condition of the skin rather than dramatically change facial shape.
Depending on the patient’s skin condition, Sunekos may improve:
- Fine lines
- Crepey skin
- Loss of firmness and elasticity
- Dryness and reduced hydration
- Enlarged pores
- Uneven skin texture
- Redness
- Dullness
- Certain types of under-eye dark circles
- Overall skin vitality
Patients often describe their concerns as:
- “My skin feels thinner than it used to.”
- “My foundation no longer sits well on my skin.”
- “My skin looks tired even when I have slept well.”
- “My complexion has become red and uneven.”
- “I want smoother skin without changing the shape of my face.”
For suitable patients, Sunekos can make the skin appear smoother, firmer, fresher, and healthier without creating an obvious “treated” appearance.
Sunekos for Redness and Dullness
At Houreisen Skin Clinic, we use Sunekos not only for fine lines and under-eye concerns, but also for facial redness and dullness when we believe these concerns are related to reduced skin quality.
In our clinical experience, Sunekos can improve the visible appearance of facial redness in appropriately selected patients.
This may be particularly relevant when redness is accompanied by:
- Dryness
- Loss of skin firmness
- Thin or fragile-looking skin
- Uneven texture
- Reduced skin hydration
- Overall decline in skin quality
Sunekos does not directly destroy or close visible blood vessels. It should therefore not be considered equivalent to vascular laser treatment.
However, as hydration, dermal condition, and overall skin quality improve, the complexion may appear less red, more even, and healthier.
The cause of facial redness must still be assessed carefully. Persistent redness may also be related to:
- Rosacea
- Visible capillaries or telangiectasia
- Inflammatory skin disease
- Irritant or allergic dermatitis
- Excessive skincare or exfoliation
- Ultraviolet exposure
When necessary, Sunekos may be combined with other treatments such as topical skincare, medication, laser treatment, chemical peels, or iontophoresis.
Can Sunekos Improve Melasma?
Sunekos is not a direct pigment-removing treatment and is not a primary treatment for melasma.
It does not directly suppress melanin production in the same way as medications or treatments specifically intended for pigmentation.
However, melasma is often accompanied by dullness, dryness, uneven texture, and reduced skin quality. In selected patients, improving hydration and the overall condition of the skin may make the complexion appear brighter and more even.
Sunekos may therefore be incorporated as an adjunctive skin-quality treatment, while the melasma itself is managed with treatments such as:
- Strict sun protection
- Oral medications
- Topical therapies
- Appropriate skincare
- Laser or light-based treatment in selected patients
- Chemical peels
- Iontophoresis or electro-infusion
The role of Sunekos is to improve the skin’s overall condition, not to claim that it directly removes melasma.
Sunekos for Fine Lines and Skin Laxity
Sunekos can improve fine wrinkles by supporting hydration, collagen production, elastin production, and the condition of the extracellular matrix.
It is particularly useful in areas with thin or delicate skin, including:
- Forehead
- Around the eyes
- Under the eyes
- Around the mouth
- Neck
Sunekos may also soften certain static wrinkles, which remain visible even when the face is at rest.
However, not all wrinkles are caused by reduced skin quality.
Wrinkles that become more noticeable during facial expressions are often strongly influenced by muscle movement. In these cases, Sunekos alone may improve the skin but may not adequately control the repeated movement that continues to deepen the wrinkle.
For this reason, combining Sunekos with Botox® may produce a more balanced and longer-lasting improvement in selected patients.
Sunekos for Under-Eye Dark Circles
Sunekos is frequently used for under-eye concerns because it can improve thin, crepey skin without creating the same structural volume as a conventional dermal filler.
Under-eye dark circles are commonly classified according to their main cause:
- Blue or vascular dark circles: underlying vessels are more visible through thin skin.
- Shadow dark circles: shadows are created by hollowness, skin laxity, protruding fat, ligaments, or facial bone structure.
- Brown or pigmented dark circles: melanin pigmentation contributes to the discoloration.
- Mixed dark circles: more than one cause is present.
Sunekos may be particularly useful when the under-eye concern is influenced by:
- Thin skin
- Fine crepey wrinkles
- Reduced firmness and elasticity
- Mild skin laxity
- Visible underlying vessels through thin skin
As the quality and firmness of the skin improve, the under-eye area may look smoother and less tired.
However, Sunekos may have limited effects when the main cause is:
- Marked protrusion of orbital fat
- A deep tear trough
- Significant skeletal shadowing
- Pronounced volume loss
- Strong pigmentation
- Severe skin laxity
These cases may require another treatment or a combination approach.
Sunekos Before-and-After Results


Understanding the Results in These Cases
Before-and-after photographs can be helpful, but results vary between patients.
The appearance of under-eye dark circles may be influenced by several factors at the same time, including:
- Skin thickness
- Visible blood vessels
- Skin pigmentation
- Protruding under-eye fat
- Tear-trough anatomy
- Facial bone structure
- Skin laxity
The same treatment will not produce the same degree of improvement in every patient. Accurate diagnosis is therefore essential before selecting treatment.
How Many Sunekos Treatments Are Recommended?
Some patients notice an improvement after a single Sunekos treatment. However, a series of treatments is generally recommended to achieve a more consistent result.
A common initial treatment schedule consists of:
- Four treatment sessions
- Each session performed approximately one to three weeks apart
The exact interval may be adjusted according to the treatment area, skin condition, degree of swelling, and the patient’s schedule.
It is best to begin the treatment course when you can attend the recommended appointments consistently.
How Long Do the Effects of Sunekos Last?
The duration of improvement varies between patients.
After completing the initial treatment course, improvements in skin firmness, texture, fine lines, and hydration may remain visible for several months.
Many patients consider maintenance treatment at approximately six-month intervals, although some patients may choose earlier or later treatment depending on:
- Age
- Skin condition
- Treatment area
- Degree of photoaging
- Lifestyle
- Individual response
Sunekos does not permanently stop the aging process. Maintenance treatment may be recommended when the patient begins to notice a gradual decline in skin quality again.
Who May Benefit from Sunekos?
Sunekos may be a good option for patients who:
- Are concerned about fine lines around the eyes
- Have fine wrinkles on the neck
- Want to improve skin firmness and elasticity
- Are bothered by enlarged pores
- Have redness related to reduced skin quality
- Have dull or tired-looking skin
- Have under-eye dark circles related to thin or lax skin
- Want gradual, natural-looking rejuvenation
- Want to improve skin quality without noticeable facial volumization
- Prefer to maintain their natural facial contours
When Sunekos Alone May Not Be Enough
Sunekos may have limited benefits when the main concern is:
- Deep nasolabial folds
- Pronounced depressions beside the nose
- Deep marionette lines
- Deep wrinkles that have become permanently etched into the skin
- Significant facial skin laxity
- Wrinkles caused mainly by strong muscle movement
- Facial depressions caused by bone structure
- Substantial loss or redistribution of facial fat
This does not mean that Sunekos is ineffective.
It means that the treatment must match the underlying cause of the concern.
Sunekos is well suited to improving skin quality, hydration, elasticity, and fine wrinkles. It is not designed to fill deep facial depressions or substantially lift sagging tissue.
Depending on the cause, a more appropriate treatment may include:
- Growth Factor Therapy
- Hyaluronic acid fillers
- Botox®
- Thread lift
- HIFU
- Radiofrequency skin tightening
- A combination of treatments
Our Approach to Sunekos Treatment
At Houreisen Skin Clinic, we tailor the injection method to each patient’s concern, treatment area, skin condition, and desired result.
Sunekos may be administered by:
- Manual injection
- Device-assisted multi-needle intradermal injection, commonly referred to in Japan as hydro injection or water-light injection therapy
Neither method is universally better. Each has different advantages.
| Injection Method | Best Suited For | Advantages |
|---|---|---|
| Manual Injection |
• Under-eye area • Around the eyes • Neck • Cheeks • Around the mouth • Localized wrinkles |
The physician can precisely adjust injection depth, amount, and placement according to the anatomy and severity of each concern. |
| Device-Assisted Multi-Needle Injection |
• Full-face treatment • Overall skin-quality improvement • Enlarged pores • Redness • Dullness • Uneven texture |
The product can be distributed evenly across a larger treatment area, making it suitable for broad improvement in hydration, texture, radiance, and pore appearance. |
For localized concerns such as under-eye fine lines or neck wrinkles, manual injection allows more detailed treatment.
When the goal is to improve the skin quality of the entire face, device-assisted multi-needle injection may provide more uniform distribution.
Making Treatment as Comfortable as Possible
Sunekos can be more uncomfortable than some other injectable skin treatments, particularly in sensitive areas such as around the eyes, forehead, and neck.
Depending on the treatment area and the patient’s needs, we may use:
- Topical anesthetic cream
- Anesthetic patches
- Cooling
- Fine needles
- Adjustment of injection speed and depth
- Other methods of pain control when appropriate
Our aim is to reduce discomfort while preserving the accuracy and effectiveness of the treatment.
Combining Sunekos with Botox®
Sunekos and Botox® address different causes of wrinkles.
| Treatment | Primary Role | Best Suited For |
|---|---|---|
| Sunekos | Improves skin quality, hydration, firmness, elasticity, fine lines, and selected under-eye concerns | Thin skin, reduced elasticity, fine crepey wrinkles, dryness, and tired-looking skin |
| Botox® | Reduces excessive muscle contraction and helps prevent expression lines from becoming deeper | Dynamic forehead lines, glabellar lines, crow’s feet, selected under-eye wrinkles, and neck bands or lines |
For example, wrinkles on the forehead and around the eyes are often caused by both:
- Reduced skin quality
- Repeated facial muscle movement
Sunekos may improve the skin itself, but the wrinkle may recur or continue to deepen if strong muscle movement remains unchanged.
By combining Botox® to reduce excessive muscle activity with Sunekos to improve the condition of the skin, we may achieve a more balanced and natural-looking result.
Combination treatment may be considered for:
- Forehead lines
- Frown lines
- Crow’s feet
- Fine under-eye wrinkles
- Neck lines
Botox® is not always necessary. The decision depends on whether the wrinkle is caused mainly by skin quality, muscle movement, or a combination of both.
How Sunekos Compares with Other Injectable Treatments
There are many injectable treatments for skin rejuvenation, including Sunekos, Rejuran, Lizne, Jalupro, Pluryal, Profhilo, hyaluronic acid fillers, and Growth Factor Therapy.
The most important question is not which treatment is universally best. It is which treatment best matches the patient’s concern.
| Treatment | Best Suited For | Key Features | Limitations |
|---|---|---|---|
| Sunekos | Fine lines, under-eye skin quality, neck wrinkles, loss of firmness, enlarged pores, redness, and dullness | Non-crosslinked hyaluronic acid combined with six amino acids to improve the extracellular matrix and overall skin quality | Limited effectiveness for deep folds, major volume loss, or significant skin laxity when used alone |
| Rejuran / Lizne | Skin regeneration, enlarged pores, fine lines, and overall skin quality | Polynucleotide-based injectable treatment | Not intended to provide major structural volume or substantially lift sagging tissue |
| Jalupro | Loss of firmness, fine lines, and mild skin laxity | Hyaluronic acid combined with amino acids | The most appropriate product and injection method depend on the treatment area and concern |
| Pluryal | Dryness, redness, dullness, fine lines, and overall skin quality | Polynucleotide-based skin-quality treatment with different formulations | Not intended to correct deep structural depressions |
| Profhilo® | Diffuse dryness, reduced elasticity, mild skin laxity, and broad skin remodeling | Hybrid high- and low-molecular-weight hyaluronic acid designed for bioremodeling | May not be the first choice for highly localized deep wrinkles or structural volume loss |
| Hyaluronic Acid Fillers | Volume loss, facial depressions, tear troughs, and deep folds | Can provide immediate structural correction | Excessive or inappropriate injection may create swelling, irregularity, or an unnatural appearance |
| Growth Factor Therapy | Nasolabial folds, loss of skin support, and gradual long-term tissue improvement | Stimulates the patient’s own regenerative response for gradual and natural-looking improvement | Results develop gradually and the degree of improvement varies between individuals |
Sunekos vs. Profhilo®
Sunekos and Profhilo® are both injectable treatments used to improve skin quality, but they differ in formulation and treatment strategy.
| Sunekos | Profhilo® | |
|---|---|---|
| Main Ingredients | Non-crosslinked hyaluronic acid combined with six amino acids | Hybrid high- and low-molecular-weight hyaluronic acid |
| Primary Role | Detailed improvement of fine lines, elasticity, skin texture, and delicate areas | Broad hydration, bioremodeling, firmness, and improvement of mild diffuse skin laxity |
| Common Strengths | Fine lines around the eyes, under-eye concerns, neck wrinkles, redness, pores, and localized skin-quality concerns | Diffuse dryness, loss of elasticity, broad facial skin remodeling, and mild laxity |
| Injection Strategy | Can be placed precisely into localized areas or distributed broadly with a multi-needle device | May be injected using standard facial protocols or customized placement according to the treatment area |
Profhilo® should not be considered a conventional volumizing filler. It spreads through the tissue and is primarily used for hydration and bioremodeling rather than contour creation.
Sunekos is often selected when we want to treat fine wrinkles or localized skin-quality concerns in detail.
Profhilo® may be preferred when the goal is broader hydration, improvement in elasticity, and remodeling of a wider area.
Sunekos or Profhilo® for the Under-Eye Area?
Both Sunekos and Profhilo® may be used around the eyes in appropriately selected patients.
At our clinic, we now use Profhilo® in the under-eye area in selected cases.
Our treatment approach has changed as our clinical experience and injection methods have evolved. We do not automatically exclude Profhilo® from the under-eye area.
However, the under-eye region has extremely thin skin and complex lymphatic and vascular anatomy. Even a small amount of product or swelling can become noticeable.
For this reason, the choice between Sunekos and Profhilo® depends on:
- The thickness and elasticity of the under-eye skin
- The presence of edema or a tendency to retain fluid
- The degree of fine wrinkling
- The presence of tear-trough hollowing
- Protruding orbital fat
- The desired degree of hydration and tissue remodeling
- The appropriate injection depth and amount
Sunekos may be preferred when the main concern is localized fine wrinkling, crepey skin, or delicate skin-quality deterioration.
Profhilo® may be considered when broader hydration and bioremodeling are desired and the patient’s anatomy and tendency toward swelling are suitable.
Neither product is automatically superior. Careful examination is necessary before selecting the product and injection method.
Is Sunekos Effective for Nasolabial Folds?
Sunekos may provide some improvement when early nasolabial folds are influenced by reduced skin firmness, reduced elasticity, or superficial skin-quality deterioration.
However, nasolabial folds are often caused by deeper structural factors, including:
- Depression beside the nose
- Cheek sagging
- Changes in facial bone structure
- Loss or redistribution of facial fat
- Weakening of the skin’s supporting structure
- Deep folding and repeated movement
When these deeper factors are dominant, Sunekos alone is unlikely to provide sufficient improvement.
Depending on the cause, we may recommend:
- Growth Factor Therapy
- Hyaluronic acid fillers
- Thread lift
- HIFU
- Radiofrequency treatment
- A combination of treatments
Is Sunekos Effective for Nasolabial Folds? A Doctor Explains Who Is and Is Not a Good Candidate
For Deeper Nasolabial Folds, Another Treatment May Be More Suitable
Sunekos is useful for improving skin quality, hydration, elasticity, and fine wrinkles.
However, deep nasolabial folds are rarely caused by poor skin quality alone.
When the fold is associated with a visible depression, reduced dermal support, or deeper structural aging, we may recommend Growth Factor Therapy.
Unlike conventional hyaluronic acid fillers, which provide improvement by adding volume, Growth Factor Therapy is intended to stimulate the patient’s own regenerative response and promote gradual tissue improvement.
Growth Factor Therapy may be suitable for patients who value:
- Gradual and natural-looking improvement
- Long-lasting changes in the treated tissue
- Improvement of the skin’s supporting structure
- A treatment that does not depend primarily on adding filler volume
At Houreisen Skin Clinic, we assess whether Sunekos, Growth Factor Therapy, hyaluronic acid fillers, thread lift, or a combination is most likely to produce a natural result.
Growth Factor Therapy for Nasolabial Folds: Does It Last Longer Than Hyaluronic Acid Fillers?
Growth Factor Therapy vs. Hyaluronic Acid Fillers: Which Is Better for Nasolabial Folds?
Risks, Side Effects, and Limitations of Sunekos
Like any injectable treatment, Sunekos can cause side effects.
Most reactions are temporary, but no injectable procedure is completely risk-free.
Swelling, Small Bumps, and Redness
Immediately after treatment, small raised areas, swelling, redness, and needle marks may appear at the injection sites.
These reactions usually improve within one to several days, although the duration varies depending on:
- The treatment area
- The injection method
- The amount injected
- Individual susceptibility to swelling
Swelling may be more noticeable and may last longer around the eyes.
Bruising
Bruising may occur wherever a needle is inserted.
It is more common in thin and highly vascular areas such as around the eyes and neck.
Most bruising gradually improves within approximately two weeks, although individual recovery times vary.
Pain and Tenderness
Sunekos can cause discomfort during injection, particularly in sensitive areas.
Tenderness may remain temporarily after treatment.
Other Possible Complications
Less common complications may include:
- Prolonged swelling
- Temporary unevenness
- Palpable firmness or nodules
- Inflammatory reactions
- Infection
- Allergic reactions
- Asymmetry
- Unsatisfactory or insufficient improvement
- Temporary worsening of redness
- Circulatory or vascular complications
At our clinic, we have not experienced vascular occlusion caused by Sunekos. Nevertheless, patients should contact the clinic promptly if they experience severe or increasing pain, marked discoloration, coldness of the skin, blistering, rapidly worsening swelling, visual symptoms, or any other unusual reaction.
Who May Need to Postpone or Avoid Treatment?
Sunekos may not be appropriate, or treatment may need to be postponed, in patients with:
- Active infection in the treatment area
- Severe active inflammation or dermatitis
- A known allergy to an ingredient
- Pregnancy or breastfeeding, according to clinic policy
- A medical condition that makes injectable treatment unsuitable
- Medication that significantly increases bleeding risk
Eligibility is determined during medical consultation.
Frequently Asked Questions
Is Sunekos Painful?
Sunekos can be more uncomfortable than some other injectable skin treatments, especially around the eyes, forehead, and neck.
At our clinic, we use appropriate anesthesia, cooling, fine needles, and carefully adjusted injection techniques to reduce discomfort as much as possible.
Where Can Sunekos Be Injected?
Sunekos can be used in many areas where skin quality has declined, including:
- Around the eyes
- Under the eyes
- Forehead
- Cheeks
- Around the mouth
- Neck
- Décolletage
- Back of the hands
The appropriate injection depth and technique differ depending on the anatomy of each area.
Manual Injection or Device-Assisted Injection: Which Is Better?
Manual injection is generally suitable for localized concerns requiring precise control of injection depth and placement.
Device-assisted multi-needle injection is generally suitable when the goal is to distribute the product evenly over a broad area, such as the full face.
The best method depends on the treatment area and desired outcome.
Does Sunekos Remain in the Body Permanently?
No. Sunekos does not contain a permanent synthetic implant.
Its non-crosslinked hyaluronic acid and amino acids are gradually metabolized by the body.
The injected product itself is temporary. However, improvement in the skin’s extracellular matrix, collagen, elastin, hydration, and overall condition may remain visible after the product has been metabolized.
Can Sunekos Improve Redness?
Yes, in our clinical experience, Sunekos can improve facial redness in appropriately selected patients.
It is particularly worth considering when redness is accompanied by dryness, thin skin, reduced elasticity, or an overall decline in skin quality.
However, redness caused mainly by rosacea, visible blood vessels, active dermatitis, or inflammation may require other treatments.
Can Sunekos Improve Melasma?
Sunekos is not a direct treatment for melasma and does not replace dedicated pigmentation treatment.
However, it may be used as part of a broader treatment plan to improve hydration, texture, dullness, and overall skin quality.
Can Sunekos Improve Deep Wrinkles?
Sunekos is most suitable for fine lines and skin-quality-related wrinkles.
Deep wrinkles caused by volume loss, bone structure, strong muscle movement, or significant skin laxity may require Growth Factor Therapy, hyaluronic acid fillers, Botox®, lifting treatment, or a combination approach.
Sunekos Pricing at Our Clinic
At our clinic, we use Sunekos Performa as our standard Sunekos product.
Because treatment plans, treatment areas, injection methods, and the number of sessions may differ, please refer to our current price list for the latest fees.
Is Sunekos Right for You?
Sunekos is a useful skin-quality treatment for concerns such as:
- Fine lines around the eyes
- Fine neck wrinkles
- Under-eye dark circles related to skin quality
- Loss of firmness and elasticity
- Enlarged pores
- Redness
- Dullness
- Uneven texture
- Dry or tired-looking skin
It is particularly suitable for patients who want to improve the condition of their skin without significantly changing facial volume or contours.
However, Sunekos has limitations.
If the main concern is:
- Deep nasolabial folds
- Pronounced marionette lines
- Significant skin laxity
- A deep tear trough
- Facial depression caused by bone structure or volume loss
- Wrinkles caused primarily by strong muscle movement
another treatment or a combination of treatments may provide a more effective result.
At Houreisen Skin Clinic, we do not recommend the same treatment to every patient.
We assess:
- Skin quality
- Muscle movement
- Facial volume
- Bone structure
- Skin laxity
- The location and depth of the concern
Based on this assessment, we may recommend Sunekos, Profhilo®, Botox®, Growth Factor Therapy, hyaluronic acid fillers, thread lift, HIFU, radiofrequency treatment, or a combination approach.
The most important question is not whether Sunekos is a good treatment. It is whether Sunekos is the right treatment for your skin.
A medical consultation can help clarify what is causing your concern and which treatment is most likely to provide a natural-looking result.










