Rejuran Skin Booster: Benefits, Downtime, Before & After, Cost & Complete Treatment Guide

Specialist Clinics for Nasolabial Fold and Wrinkle Treatment
Osaka Houreisen Skin Clinic / Tokyo Houreisen Skin Clinic / Nagoya Houreisen Skin Clinic
Author: Shinya Sasagawa, MD
Physician, Shingetsukai Medical Corporation
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Rejuran Skin Booster Treatment in Japan

International patients are welcome at our clinics in Osaka, Tokyo, and Nagoya.

Rejuran is a polynucleotide-based injectable treatment designed for patients who want to improve fine lines, firmness, enlarged pores, and overall skin texture without noticeably changing their facial contours.

A doctor will assess your skin condition and recommend an appropriate treatment based on your concerns, desired results, available downtime, and length of stay in Japan.

English-language assistance may be available depending on the clinic and appointment date. Please contact us in advance if you require support in English.

Rejuran at a Glance

Rejuran is an injectable skin treatment formulated with polynucleotides, or PN, purified from salmon-derived DNA fragments.

Rather than adding visible volume in the way dermal fillers do, Rejuran is designed to support the skin’s natural repair environment and gradually improve firmness, elasticity, texture, and fine lines.

It may be particularly suitable for:

Fine and crepey lines: Fine lines around the eyes, mouth, and cheeks
Loss of firmness or elasticity: Skin that feels thinner, looser, or less resilient
Visible pores and uneven texture: Roughness or enlarged pores
Natural-looking rejuvenation: Gradual skin-quality improvement without noticeably changing facial shape

Rejuran is not designed to fill deep nasolabial folds, replace significant volume loss, or lift pronounced sagging on its own. Depending on the cause of your concern, hyaluronic acid filler, Growth Factor Injection Treatment, thread lifting, HIFU, or radiofrequency treatment may be more appropriate.

As the skin ages, many people begin to notice fine lines around the eyes, more visible pores on the cheeks, reduced firmness, and a tired or less radiant appearance.

Skin boosters have become increasingly popular because they focus on improving the condition and quality of the skin itself rather than simply adding facial volume.

Available skin-booster treatments include Rejuran, Vitaran, Sunekos, Pluryal Densify, Profhilo, and Jalupro.

Each treatment has a different formulation and clinical role. The most appropriate option should be selected according to your skin condition and goals rather than popularity alone.

Consultations Are Free

A doctor will assess your skin and discuss whether Rejuran is suitable for you. We only recommend treatment when it is appropriate for your condition and aligned with your goals.

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What Is Rejuran?

Rejuran is an injectable treatment that delivers polynucleotides into the superficial layers of the skin. It is designed to support the skin’s repair environment and gradually improve firmness, elasticity, texture, and fine lines.

In Korea, it is widely known as “Rejuran Healer” and is commonly selected by patients who want subtle, progressive skin improvement rather than an immediate change in facial shape.

PN is purified from salmon-derived DNA fragments. During manufacturing, impurities are removed and the material is processed for use as a medical injectable product.

Patients with a significant allergy to fish, salmon, or fish roe should inform their doctor before treatment.

Focuses on Skin Quality

Supports the skin’s repair environment and helps support collagen and extracellular-matrix remodelling.

Gradual, Natural-Looking Results

Rejuran does not dramatically reshape the face. Changes in texture and firmness usually develop gradually over several weeks.

Who May Benefit from Rejuran?

✓ People concerned about fine or crepey lines around the eyes, mouth, or cheeks
✓ People experiencing reduced skin firmness or elasticity
✓ People who want to improve visible pores, roughness, or uneven texture
✓ People concerned about mild acne scarring or residual redness
✓ People who want to improve skin quality without noticeably changing their facial contours
✓ People seeking gradual and natural-looking skin rejuvenation

When Rejuran May Not Be Enough on Its Own

You want deep nasolabial folds or marionette lines improved immediately
You want significant cheek sagging lifted
You want to correct pronounced hollowing in the cheeks, temples, or under-eye area
You expect a dramatic change after one treatment session
You want to avoid injection discomfort or temporary raised bumps

Rejuran is primarily a skin-quality treatment. Deep folds and volume loss may be better addressed with hyaluronic acid filler. Expression lines caused by muscle movement may be treated with Botox, while pronounced sagging may require thread lifting, HIFU, or radiofrequency treatment.

If nasolabial folds are your main concern
Nasolabial folds are influenced by multiple factors, including skin quality, facial bone structure, fat distribution, cheek descent, and muscle movement. For more information, please see our complete guide to the causes and treatment of nasolabial folds.

What Are Polynucleotides?

Polynucleotides are chains of nucleotides, which are components of DNA.

When injected into the skin, polynucleotides are thought to support the local repair environment, fibroblast activity, and collagen formation.

Function	How It May Help	Potential Benefits
Supports Skin Repair	Helps create a favourable environment for skin repair and restructuring.	Smoother texture and healthier-looking skin
Supports Fibroblast Activity	Supports the production of collagen and other structural components within the dermis.	Improved firmness, elasticity, and fine lines
Supports the Skin Environment	May support skin affected by inflammation, dryness, or environmental stress.	Supportive improvement in redness and uneven tone

Results vary between individuals. No treatment can guarantee improvement in every skin concern.

What Results Can You Expect?

1. Improved Firmness and Elasticity

By supporting the dermal repair environment and collagen production, Rejuran may help the skin appear firmer, more resilient, and better supported.

2. Softer Fine and Crepey Lines

Rejuran is often used in delicate areas such as the under-eyes, mouth, and cheeks, where fine lines and crepey texture are common.

3. Refined Pores and Smoother Texture

As skin firmness and texture improve, enlarged or laxity-related pores may become less noticeable.

4. Supportive Improvement in Mild Acne Scarring

Rejuran may help improve shallow unevenness and overall post-acne skin quality. Deeper scars may require combination treatment with Potenza, needle radiofrequency, or subcision.

5. Support for Red or Stressed Skin

By supporting the skin environment, Rejuran may help skin affected by dryness, inflammation, or ultraviolet exposure appear calmer and more even.

When Will I See Results?

Unlike hyaluronic acid filler, Rejuran does not reshape the face immediately.

It works through gradual skin repair and remodelling. Many patients begin to notice changes in firmness, texture, or radiance approximately two to four weeks after treatment.

Recommended Course	Approximately three sessions
Treatment Interval	Once every three to four weeks
When Results May Develop	Gradually, from approximately two to four weeks
Maintenance	Every few months to six months, depending on the skin condition

Some patients notice improved glow or firmness after one treatment. However, a course of multiple sessions is generally recommended for more consistent skin-quality improvement.

The recommended number of sessions varies depending on age, skin type, treatment area, and treatment goals.

Treatment Areas

Around the Eyes

Rejuran may be suitable for under-eye lines, crow’s feet, crepey texture, thin skin, and reduced firmness.

Cheeks and Full Face

It may be used for visible pores, uneven texture, reduced firmness, shallow acne scarring, and fine lines caused by dryness.

Around the Mouth and Nasolabial Folds

Rejuran may be used for fine vertical lines around the mouth and reduced firmness around the nasolabial folds. However, it does not directly fill a deep nasolabial fold.

Please also see our article about the benefits and limitations of Rejuran for nasolabial folds.

Neck

Rejuran may be used for crepey neck lines, dryness, and reduced firmness. Deeper horizontal neck lines may require combination treatment.

Is Rejuran Painful?

Rejuran is injected in multiple small deposits into the superficial layers of the skin. It is therefore considered one of the more uncomfortable skin-booster treatments.

Patients may feel repeated pinpricks, pressure, or stinging as the product enters the skin. Areas around the eyes, nose, and mouth may be particularly sensitive.

How We Reduce Discomfort

Topical anaesthetic cream before treatment
Fine-gauge injection needles
Optional nerve-block injections for sensitive areas
Cooling when appropriate
Careful pacing and communication throughout the procedure

Pain sensitivity varies between individuals. Please let us know during your consultation if you are particularly concerned about discomfort.

Downtime and Possible Side Effects

Temporary small raised injection bumps, sometimes described as resembling mosquito bites, are expected immediately after treatment.

These bumps are caused by small deposits of product within the superficial layers of the skin and gradually settle as the product disperses.

Possible Reaction	Typical Course
Small Raised Bumps	Usually improve within several hours to two days. Depending on the treatment area and injection volume, they may occasionally remain for approximately three days.
Redness, Swelling, or Puffiness	Usually improves within the same day to several days. Puffiness may be more noticeable around the eyes.
Bruising	Bruising may occur if a small blood vessel is affected. It usually fades gradually over one to two weeks.
Tenderness	Mild tenderness at the injection sites may continue for several days.
Rare Complications	Infection, allergic reaction, marked swelling, nodules, persistent redness, or other prolonged symptoms.

If you experience severe pain, marked swelling, worsening redness, fever, discharge, breathing difficulty, or other concerning symptoms, please contact the clinic promptly.

If you have an important event, wedding, professional photo session, or public appearance, we recommend allowing one to two weeks for possible swelling or bruising.

For patients visiting Japan
If you are visiting Japan for a short stay, please schedule your treatment with enough time for possible swelling, raised bumps, and bruising to settle before an important event or departure.

Aftercare

Important Instructions After Treatment

Face Washing and Skincare
Cleanse gently with clean hands and avoid rubbing the treated areas. Follow the instructions provided by the clinic regarding when to restart cleansing products and skincare.

Makeup
Avoid makeup immediately after treatment to reduce irritation and the risk of contamination through the injection sites. After manual injection by a doctor, makeup may usually be applied approximately one hour after treatment. After treatment with an automated skin-booster injector, makeup may generally be applied from the following day. Instructions may vary depending on your skin condition, so please follow the guidance provided after your procedure.

Baths, Alcohol, Exercise, and Saunas
Increased blood circulation may worsen redness, swelling, or bruising. Avoid long baths, alcohol, saunas, and strenuous exercise on the day of treatment.

Massage and Pressure
Avoid strong massage, pressure, friction, or treatments that compress the injection areas for approximately one week.

Sun Protection and Moisturising
The skin may be temporarily sensitive after treatment. Use sunscreen and moisturiser and temporarily avoid harsh exfoliants, scrubs, retinoids, or other irritating skincare products.

What to Expect on the Day

Treatment Time	Approximately 40 to 60 minutes, including anaesthetic time. Consultation time is not included.
Anaesthesia	Topical anaesthetic cream, with optional nerve-block anaesthesia depending on the treatment area and pain sensitivity
Injection Method	Manual injection by a doctor or treatment using an automated skin-booster injector Learn about manual injection and automated skin-booster injection

1. Consultation and Medical Assessment

We will discuss your concerns, skin condition, allergies, medical history, medications, desired results, and available downtime before determining whether treatment is appropriate.

2. Cleansing and Photography

The skin is cleansed, and clinical photographs may be taken to document the condition before treatment and evaluate subsequent changes.

3. Topical Anaesthesia

Anaesthetic cream is applied and left in place for an appropriate period to reduce discomfort.

4. Treatment Planning and Injection

The product is injected carefully according to the treatment area, skin thickness, and individual concerns.

5. Cooling and Aftercare

Cooling or gentle compression may be performed when necessary. You will receive instructions regarding skincare, activity restrictions, and symptoms to monitor.

Rejuran Compared with Other Skin Boosters

Treatment	Main Ingredient	May Be Suitable For	Key Feature
Rejuran	PN	Fine lines, reduced firmness, visible pores, uneven texture, and skin repair	Focuses on supporting skin repair and dermal remodelling
Vitaran	PN	Fine lines around the eyes and mouth and reduced firmness	A PN product with its own concentration, molecular profile, and viscosity
Sunekos	Non-crosslinked hyaluronic acid and amino acids	Fine lines around the eyes, forehead, and neck and natural-looking firmness	Supports collagen and elastin production
Pluryal Densify	PN, non-crosslinked hyaluronic acid, and mannitol	Firmness, radiance, dryness, redness, and uneven skin tone	Combines skin repair support with hydration
Profhilo	High- and low-molecular-weight hyaluronic acid	Full-face or neck firmness, elasticity, and mild laxity	Distributes over a wider area from a relatively small number of injection points
Hyaluronic Acid Filler	Crosslinked hyaluronic acid	Deep wrinkles, hollowing, facial support, and contouring	Adds volume directly and produces an immediate structural change
Botox	Botulinum toxin	Expression lines on the forehead, between the eyebrows, or around the eyes	Reduces targeted muscle activity

Rejuran vs. Hyaluronic Acid Filler

Hyaluronic acid filler is a gel-based injectable used to replace volume in hollows and deep folds. It can produce an immediate structural change.

Rejuran, by comparison, supports the skin’s repair environment and gradually improves skin texture and firmness. Hyaluronic acid filler may be more appropriate when the goal is to improve a deep fold or hollow, while Rejuran may be considered when the main concerns are thin skin, fine lines, and overall skin quality.

For patients concerned about nasolabial folds, please also see our guide to Growth Factor Injection Treatment and hyaluronic acid filler.

Rejuran vs. Sunekos

Rejuran is PN-based and focuses on supporting dermal repair, firmness, and texture.

Sunekos combines non-crosslinked hyaluronic acid with amino acids and is designed to support collagen and elastin production. Both treatments may be used around the eyes or forehead, with the choice depending on skin condition, treatment area, pain sensitivity, and downtime preference.

For more information, please see our detailed guide to Sunekos injections.

Rejuran vs. Pluryal Densify

Both treatments contain PN. However, Pluryal Densify also contains non-crosslinked hyaluronic acid and mannitol.

Rejuran may be considered when supporting skin repair is the main priority. Pluryal Densify may be considered when hydration, radiance, dryness, redness, or uneven tone are also important concerns.

For more information, please see our guide to the effects and features of Pluryal Densify.

Who Should Avoid Rejuran or Seek Medical Advice First?

Patients who are pregnant or breastfeeding
Patients with infection, active inflammation, or skin disease in the treatment area
Patients with a severe allergy to fish, salmon, fish roe, or fish-derived ingredients
Patients with a history of significant allergic reactions to injectable products
Patients taking anticoagulant or antiplatelet medication
Patients with a serious underlying medical condition or autoimmune disease

Please inform the doctor about all medications, supplements, allergies, medical conditions, and ongoing treatments before the procedure.

Do not stop prescription medication without consulting the doctor who prescribed it.

Rejuran Treatment Fees

Treatment	Fee
Rejuran 2 cc	¥65,000 including tax

Fees may vary depending on the injection method, treatment volume, treatment area, and current promotions. Please confirm the latest fee before booking or during your consultation.

View the Houreisen Skin Clinic Price List

Frequently Asked Questions

How many Rejuran sessions will I need?

Depending on your skin condition, we often recommend approximately three sessions at intervals of three to four weeks. Maintenance treatment may then be considered according to your skin condition and goals.

When will I see results?

Because Rejuran works through gradual skin repair and remodelling, many patients notice changes in firmness or texture over approximately two to four weeks.

Is Rejuran painful?

Multiple small injections may cause repeated pinprick discomfort, pressure, and stinging. We use topical anaesthetic cream, fine needles, and other measures to reduce discomfort.

How long do the small raised bumps last?

They usually become less noticeable within several hours to two days. Depending on the injection volume, treatment area, and skin condition, they may occasionally remain for approximately three days.

How long is the downtime?

Raised bumps, redness, and swelling usually improve within several hours to a few days. If bruising occurs, it may take approximately one to two weeks to fade.

Can Rejuran improve enlarged pores?

As firmness and skin texture improve, enlarged or laxity-related pores may become less noticeable. If excess sebum or deep acne scarring is the main cause, treatments such as Potenza may be more appropriate.

Can Rejuran help acne scars?

Rejuran may support improvement in shallow unevenness, redness, and overall skin quality. Deeper crater-like acne scars often require needle radiofrequency, subcision, or combination treatment.

Does Rejuran work for nasolabial folds?

Rejuran may improve fine lines and reduced firmness around the nasolabial folds. However, it does not directly fill a deep groove caused by bone structure, volume loss, or cheek descent. Other treatments may be more appropriate depending on the cause.

What is the difference between Rejuran and Vitaran?

Both are PN-based injectable skin treatments. Their PN concentration, molecular characteristics, viscosity, and distribution within the skin may differ. The product is selected according to the treatment area, skin condition, and treatment goals.

Which is better: Rejuran or hyaluronic acid filler?

The treatments have different purposes. Hyaluronic acid filler may be suitable for directly improving a hollow or deep wrinkle. Rejuran may be suitable for gradually improving firmness, fine lines, and skin texture. If nasolabial folds are your main concern, the most appropriate treatment should be selected according to the cause.

Can I have Rejuran if I have a fish allergy?

Please inform your doctor if you have an allergy to fish, salmon, or fish roe. Rejuran may not be recommended for patients with a severe allergy to fish-derived ingredients.

Can international visitors receive treatment?

Yes. International patients are welcome at our Osaka, Tokyo, and Nagoya clinics. Please contact us in advance and provide your preferred clinic, treatment date, skin concerns, length of stay in Japan, and whether you require English-language assistance.

Can I fly after Rejuran treatment?

Flying is generally possible after treatment. However, raised bumps, swelling, or bruising may still be visible. Please discuss your travel schedule with us in advance, especially if you are leaving Japan shortly after treatment.

Summary

Rejuran is a PN-based injectable skin treatment designed to support the skin’s repair environment and gradually improve firmness, elasticity, fine lines, visible pores, and overall texture.

It may be a suitable option for patients who want natural-looking skin improvement without adding obvious facial volume or noticeably changing their facial contours.

However, temporary raised bumps, redness, swelling, bruising, and injection discomfort may occur.

Rejuran is not designed to correct deep nasolabial folds, significant hollowing, or pronounced sagging on its own. Depending on the cause of your concern, hyaluronic acid filler, Botox, Growth Factor Injection Treatment, thread lifting, HIFU, radiofrequency treatment, or a combination approach may be more appropriate.

Skin-booster products have different ingredients and clinical roles. A medical assessment is important to determine whether Rejuran is appropriate for your skin condition and treatment goals.

International Patients Are Welcome

Consultations are available at our clinics in Osaka, Tokyo, and Nagoya.

A doctor will assess your skin and recommend the treatment best suited to your goals. If Rejuran is not the most appropriate option, we will explain suitable alternatives.

When contacting us, please include your preferred clinic, desired appointment date, treatment area, main concerns, length of stay in Japan, and whether you require English-language assistance.

Request an English Consultation Book an Appointment